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   Max-Net Alumni

Forschungsbericht / Research Report :
 
 

Position open: 1 Technician
Alzheimer Disease Research / Mandelkow lab @ DESY, Hamburg

Positions open: 1 Technician, 1 Postdoc
Alzheimer Disease Research / Mandelkow lab @ DZNE, Bonn

       

 Arbeitsgruppe Zytoskelett 

 Leiter :
 Prof. Dr. Eckhard Mandelkow 

 Publikationen 

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Kinesin Motorprotein läuft am Mikrotubulus
Motor protein kinesin walks along microtubule

Kinesin am Mikrotubulus
Kinesin on microtubule

Paired helical filaments
of Tau protein

"Morris Water Maze" swim test to probe memory:

Mice are trained to find and
 remember a platform (white circle).

Short path = good memory (left and right),
long path = poor memory (middle).
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(a) Control mouse remembers
and finds platform quickly

(b) Mouse with tau pathology
 cannot remember and
 takes a long time to find platform

(c) Same mouse as (b), but after
 switching Tau off for 4 weeks:
 Memory has recovered
back to normal